PROFILE

안준용 교수

Brain organoid-based virtual cell modeling predicts novel autism and neurodevelopmental disorder genes

Brain organoid-based virtual cell modeling combines single-cell transcriptomics with AI-driven methodologies to predict novel genes associated with autism and neurodevelopmental disorders.
Utilizing the comprehensive Neural Organoid Cell Atlas with Perturbation, this approach uncovers critical genes that conventional genomic analyses typically miss.

고려대학교 바이오시스템의과학부

EDUCATION

2012.4-2016.1 Ph.D., Neuroscience, University of Queensland, Australia
2010.2-2011.12 M.Sc., Molecular Biology, University of Queensland, Australia
2005.3-2010.2 B.Sc., Molecular Biotechnology, Konkuk University, South Korea

PROFESSIONAL EXPERIENCE

2022-Present, Associate Professor, Korea University
2019-2022, Assistant Professor, Korea University
2015-2019 Postdoctoral Fellow, University of California, San Francisco

RESEARCH ACTIVITIES & OTHERS

Kim JP*, Cho M*, Kim C*, (...), Seo SW**, An JY**, Won HH**, Whole-genome sequencing analyses suggest novel genetic factors associated with Alzheimer’s disease and a cumulative effects model for risk liability, Nature Communications, 2025
Kim SW*, Lee H*, (...), Kim EJ**, Werling DM**, Yoo HJ**, An JY**, Whole genome sequencing analysis identifies sex differences of familial pattern contributing to phenotypic diversity in autism. Genome Medicine, 2024
Song KJ*, Choi S*, Kim K*, Hwang HS*, (...), Na S**, Jang SJ**, An JY**, Kim KP**, Proteogenomic Analysis of a Korean Cohort Reveals Lung Cancer Subtypes Predictive of Metastasis, Chromosome Instability, and Tumor Microenvironment, Nature Communications, 2024
An JY** & Kim Y, Genomic patterns in the schizophrenia brain. Science, 2024
Kim Y*, Jeong M*, (...), An JY**, CWAS-Plus: Estimating category-wide association of rare noncoding variation from whole-genome sequencing data with cell-type-specific functional data, Briefings in Bioinformatics, 2024

PUBLICATIONS

1. Kim SW*, Lee H*, Song DY, Lee GH, Ji J, Park JW, Han JH, Lee JW, Byun HJ, Son JH, Kim YR, Lee
Y, Kim J, Jung A, Lee JH, Kim EH, Kim SH, Lee JH, Satterstrom FK, Girirajan S, Børglum AD, Grove
J, Kim EJ**, Werling DM**, Yoo HJ**, An JY**, Whole genome sequencing analysis identifies sex
differences of familial pattern contributing to phenotypic diversity in autism. Genome Medicine, 2024
2. Kim JH*, Koh IG, Lee H, Lee GH, Song DY, Kim SW, Kim Y, Han JH, Bong G, Lee J, Byun H, Son JH,
Kim YR, Lee Y, Kim JJ, Park JW, Kim IB, Choi JK, Jang JH, Trost B, Lee J, Kim E, Yoo HJ**, An JY**,
Short tandem repeat expansions in cortical layer-specific genes implicate in phenotypic severity and
adaptability of autism spectrum disorder, Psychiatry and Clinical Neurosciences, 2024
3. Song KJ*, Choi S*, Kim K*, Hwang HS*, Chang E, Park JS, Shim SB, Choi S, Heo YJ, An WJ, Yang
DY, Cho KC, Ji W, Choi CM, Lee JC, Kim HR, Yoo J, Ahn HS, Lee GH, Hwa C, Kim S, Kim KG, Kim
MS, Paek E, Na S**, Jang SJ**, An JY**, Kim KP**, Proteogenomic Analysis of a Korean Cohort
Reveals Lung Cancer Subtypes Predictive of Metastasis, Chromosome Instability, and Tumor
Microenvironment, Nature Communications, 2024
4. Kim Y*, Jeong M*, Koh IG, Kim C, Lee H, Kim JH, Yurko R, Kim IB, Park J, Werling DM, Sanders SJ,
An JY**, CWAS-Plus: Estimating category-wide association of rare noncoding variation from wholegenome
sequencing data with cell-type-specific functional data, Briefings in Bioinformatics, 2024
5. Darbandi SF*, An JY*, Lim K, Page NF, Liang L, Young DM, Ypsilanti AR, State MW, Nord AS, Sanders
SJ**, Rubenstein JLR**, Five autism-associated transcriptional regulators target shared loci proximal
to brain-expressed genes, Cell Reports, 2024