희귀유전질환심포지엄조직위원회
Rare Genetic Disease Symposium Organizing Committee
PROFILE

최무림 교수

Functional genomics approach to understand rare neurological diseases
I will present our recent effort to understand genetic mechanism underlying neurological diseases using functional genomics approaches, such as single cell sequencing, spatial transcriptomics, CRISPR-screening, and lineage tracing.
서울대학교 의과대학
EDUCATION
1994.3-1998.2. B.S. Seoul National University
1998.3-2000.2. M.S. Seoul National University
2001.9-2006.12. PhD. Duke University
PROFESSIONAL EXPERIENCES
Associate research scientist with Dr. Richard Lifton (Jul. 2010 - Feb. 2013)
Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine
Postdoc associate with Dr. Richard Lifton (Jul. 2007 - Jun. 2008 and Jul. 2009 - Jun. 2010)
Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine
Postdoc fellow with Dr. Richard Lifton (Jul. 2008 - Jun. 2009)
Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine
PUBLICATIONS
1. Sim, H., Park, G.-H., Park, W.-Y., Lee, S.-H.,† Choi, M.† Single-cell-eQTL mapping in circulating immune
cells reveals genetic regulation of response-associated networks in lung cancer immunotherapy. Cancer
Commun. (2025) in press
2. Hong, S. E., Mun, S. J., Lee, Y. J., Yoo, T., Suh, K.-S., Kang, K. W., Son, M. J., Kim, W.,† Choi, M.†
Identification of genes conferring individual-level variation responsible for metabolic dysfunctionassociated
steatohepatitis using single-cell eQTL analysis. Nat. Genet. (2025) in press
3. Moon, H.,* Kim, M.,* Sim, H.,* Hong, S., Jeon, H., Cho, J.,† Choi, M.† Comprehensive profiling of
genetic and non-genetic factors that influence skin traits in Asian women from four countries. J. Invest.
Dermatol. (2025) in press
4. Jeon, E. Y., Kwak, Y., Kang, H., Jin, S. Y., Park, S., Kim, R. G., Ko, D., Won, J.-K., Cho, A., Jung, I., Lee,
C.-H., Park, J., Kim, H.-Y., Chae, J.-H.,† Choi, M.† Inhibiting EZH2 complements steroid effects in
Duchenne muscular dystrophy. Sci Adv. (2025) 11:eadr4443.
5. Sim, H., Park, H. J., Park, G. H., Kim, Y. J., Park, W. Y., Lee, S. H.,† Choi, M.† Increased inflammatory
signature in myeloid cells of non-small cell lung cancer patients with high clonal hematopoiesis burden.
Elife. (2024) 13:RP96951.
