희귀유전질환심포지엄조직위원회
Rare Genetic Disease Symposium Organizing Committee
PROFILE
오수환 교수
Proximity-Induced Chemical Based Strategy to Reprogram Pathogenic Transcription and Restore Therapeutic Gene Expression
We are developing a TCIP-based transcriptional regulation platform using bivalent small molecules.
In our model system, AP1867-JQ1 physically bridges PPARγ-FKBP^F36V and endogenous BRD4, enhancing PPARγ-driven transcription.
This proximity induction upregulates adipocyte differentiation markers and synergizes with conventional PPARγ ligands.
Based on this principle, we aim to extend chemical proximity-based transcriptional rewiring to rare diseases.
By recruiting transcriptional regulators or chromatin effectors to disease-relevant loci, this strategy may restore beneficial gene expression without permanent genome editing.
고려대학교 약학대학
EDUCATION
2012-2018, Ph.D., Biological Science Graduate Program, University of California, San Diego, CA
2007-2009, M.S., Department of Molecular and Cellular Biology Korea University, Seoul, Korea
2000-2007, B.Sc., Division of Life Sciences, College of Life Sciences, Korea University, Seoul, Korea
Professional Experience
2022-Present, Associate Professor in College of Pharmacy, Korea Univ. Sejong, South Korea
2018-2022, Postdoctoral Fellow in Howard Hughes Medical Institute University of California, San Diego, CA
RESEARCH ACTIVITIES & OTHERS
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Hwang JY, Kim SH, Kim JK, Oh S. Programmable Bacterial Contractile Injection Systems for Ag Delivery and CD8+ T Cell Activation. Immune Network. 2026 Apr 13;26(3):e20.
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Hwang WY, Rosenfeld MG, Oh S+, Kwon YC+. Liquid-liquid phase separation mediated immune evasion of respiratory syncytial virus against oligoadenylate synthetase-RNase L pathway. Plos Pathogens. 2026 Mar 27;22(3):e1014089.
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Lee H, Friedman MJ, Kim SB, Oh S. DNA regulatory element cooperation and competition in transcription. BMB Reports. 2024 ;57:509-520.
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Friedman MJ, Wagner T, Lee H, Rosenfeld MG+, Oh S+. Enhancer–promoter specificity in gene transcription: molecular mechanisms and disease associations. Experimental & Molecular Medicine. 2024 Apr 25:1-6.
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Friedman, M.J., Lee, H., Lee, J.Y+. and Oh, S+., 2023. Transcriptional and epigenetic regulation of context-dependent plasticity in T-helper lineages. Immune Network, 23(1).