PROFILE

오영택 교수

Pathway based analysis of glioblastoma by multi-omics with master kinase analysis in targeted therapy

Glioblastoma was classified into four functional subtypes each exhibiting distinct prognostic and therapeutic implications. Using an integrative machine learning-based proteomic/phosphoproteomic network, PKC-δ and DNA-PKcs were identified and validated as key master kinases driving the GPM and PPR subtypes, respectively. These findings offer actionable therapeutic targets and a robust framework for patient stratification in prospective clinical trials and retrospective therapeutic response evaluations.

강원대학교 생명과학과

EDUCATION

2011-2018, M.S. & Ph.D. in Health Sciences and Technology, Sungkyunkwan University

2006-2010, B.S. in Bio-technology, Yonsei University

PROFESSIONAL EXPERIENCE

2024-Present, Assistant professor, Kangwon National University

2022-2024, Associate scientist, University of Miami

2018-2022, Postdoctoral research scientist, Columbia University

2015-2018, Researcher, Korea National Cancer Center

RESEARCH ACTIVITIES & OTHERS

Wang C*, Sun T*, He Y, Yu M, Pan C, Hu H, Sun Y, Wang D, Cui Z, Zhang J, Zhai Y, Shi Z, Li Z, Xu M, Oh YT, Jiang T, Xu Z**, Li G**, Zhang J**, Zhang W**. A Deep Learning–Driven Framework Integrating Organoid-Based Functional Validation Identifies Universal Neoantigens from Recurrent Glioma Mutations. Cancer Research. (2026)
Nomura M*, Spitzer A*, Johnson KC*, Garofano L*, Nehar-Belaid D, Darnell NG, Greenwald AC, Bussema L, Oh YT, Varn FS, D'Angelo F, Gritsch S, Anderson KJ, Migliozzi S, Castro LNG, Chowdhury T, Robine N, Reeves C, Park JB, Lipsa A, Hertel F, Golebiewska A, Niclou SP, Nusrat L, Kellet S, Das S, Moon HE, Paek SH, Bielle F, Laurenge A, Stefano ALD, Mathon B, Picca A, Sanson M, Tanaka S, Saito N, Ashley DM, Keir ST, Ligon KL, Huse JT, Yung WKA, Lasorella A**, Verhaak RGW**, Iavarone A**, Suvà ML**, Tirosh I**. The multilayered transcriptional architecture of glioblastoma ecosystems. Nature Genetics. (2025)
Spitzer A*, Johnson KC*, Nomura M*, Garofano L*, Nehar-Belaid D, Darnell NG, Greenwald AC, Bussema L, Oh YT, Varn FS, D'Angelo F, Gritsch S, Anderson KJ, Migliozzi S, Castro LNG, Chowdhury T, Robine N, Reeves C, Park JB, Lipsa A, Hertel F, Golebiewska A, Niclou SP, Nusrat L, Kellet S, Das S, Moon HE, Paek SH, Bielle F, Laurenge A, Stefano ALD, Mathon B, Picca A, Sanson M, Tanaka S, Saito N, Ashley DM, Keir ST, Ligon KL, Huse JT, Yung WKA, Lasorella A**, Iavarone A**, Verhaak RGW**, Tirosh I**, Suvà ML**. Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics. Nature Genetics. (2025)
Kim K*, Migliozzi S*, Koo H*, Hong J, Park SM, Kim S, Kwon HJ, Ha S, Garofano L, Oh YT, D'Angelo F, Kim CI, Kim S, Ji Lee JY, Kim J, Hong J, E, Mathon B, Stefano ALD, Bielle F, Laurenge A, Nesvizhskii AI, Hur E, Yin J, Shi B, Kim Y, Moon K, Kwon JT, Lee SH, Lee SH, Gwak HS, Lasorella A, Yoo H, Sanson M**, Sa JK**, Park C**, Nam D**, Iavarone A**, Park JB**. Integrated proteogenomic characterization of glioblastoma evolution. Cancer Cell. (2024)
Jeon H*, Kim J, Cho HJ, Lee WJ, Nguyen D, Kim SS, Oh YT, Kim H, Jung C, Pinero G, Joshi T, Hambardzumyan D, Sakaguchi T, Hubert CG, McIntyre TM, Fine HA, Gladson CL, Wang B, Purow BW, Park JB, Park MJ, Nam D, Lee J**. Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling. Cancer Cell. (2023)
Migliozzi S*, Oh YT*, Hasanain M*, Garofano L*, D’Angelo F, Najac RD, Picca A, Bielle F, Stefano ALD, Lerond J, Sarkaria JN, Ceccarelli M, Sanson M, Lasorella A**, Iavarone A**. Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy. Nature Cancer. (2023)
Garofano L*, Migliozzi S*, Oh YT*, D’Angelo F, Najac RD, Ko A, Frangaj B, Caruso FP, Yu K, Yuan J, Zhao W, Stefano ALD, Bielle F, Jiang T, Sims P, Suvà ML, Tang F, Su X, Ceccarelli M, Sanson M, Lasorella A**, Iavarone A**. Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities. Nature Cancer. (2021)