PROFILE

김배훈 이사

Targeting a Novel Pathological Mechanism in Glioblastoma: An Anti-Cancer Peptide and Brain-Targeted Delivery

In this presentation, we will introduce an anti-cancer peptide based on a novel pathological mechanism of glioblastoma (GBM), as well as applications of a brain-targeted delivery platform derived from that peptide.

PRG S&Tech 연구본부

EDUCATION

2000-2004, Ph.D., Molecular biology/ Microbiology, Korea University

1998-2000, M.Sc., Molecular biology/ Microbiology, Korea University

1992-1998, B. Sc., Biology, Korea University

PROFESSIONAL EXPERIENCE

2021-Present, Research Director, PRG S & T Rare Disease Research Center

2021-Present, Adjunct Professor, Department of Molecular Biology Pusan University

2015-2021, Research Specialist, Howard Hughes Medical Institute in Yale University

2010-2015, Associate Research Scientist, Yale University

2005-2010, Post-Doctoral Associate, Yale University

2004-2005, Research Assistant Professor, Biotechnology Institute in Korea University

PUBLICATIONS

Kim BH, Chung YH, Woo TG, Kang Sm, Park S, Kim M, Park B-J. NF2-Related Schwannomatosis (NF2): Molecular Insights and Therapeutic Avenues. International Journal of Molecular Sciences. 2024 25(12):6558.
Zhu S*, Bradfield CJ*, Mamińska A*, Park ES*, Kim BH*, Kumar P, Huang S, Kim MJ, Zhang Y, Bewersdorf J, MacMicking JD (2024) “Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection” Science 383(6686):eabm9903 (* equal contribution)
Kim BH, Chung YH, Woo TG, Kang SM, Park S, Park BJ. (2023) “Progerin, an Aberrant Spliced Form of Lamin A, Is a Potential Therapeutic Target for HGPS.” Cells 12(18):2299
Kang SM, Seo S, Song EJ, Kweon O, Jo AH, Park S, Woo TG, Kim BH, Oh GT, Park BJ. (2023) “Progerinin, an Inhibitor of Progerin, Alleviates Cardiac Abnormalities in a Model Mouse of Hutchinson-Gilford Progeria Syndrome.” Cells 12(9):1232
Kim BH, Woo TG, Kang SM, Park S, Park BJ. (2022) “Splicing Variants, Protein-Protein Interactions, and Drug Targeting in Hutchinson-Gilford Progeria Syndrome and Small Cell Lung Cancer.” Genes (Basel) 2022 13(2):165
Cho JH, Park S, Kim S, Kang SM, Woo TG, Yoon MH, Lee H, Jeong M, Park YH, Kim H, Han YT, Suh YG, Kim BH, Kwon Y, Yun HW# and Park BJ# (2022) “RKIP induction promotes tumor-differentiation via SOX2 reduction in NF2 deficient conditions” Molecular Cancer Research 20(3):412-424
Woo TG, Yoon MH, Kang SM, Park S, Cho JH, Hwang YJ, Ahn J, Jang H, Shin YJ, Jung EM, Ha NC, Kim BH, Kwon Y, Park BJ (2021) “Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron- loss and ameliorates disease symptoms in ALS mouse model.” Communications Biology 4(1):1397
Gaudet RG, Zhu S, Halder A, Kim BH, Bradfield CJ, Huang S, Xu D, Mamiñska A, Nguyen TN, Lazarou M, Karatekin E, Gupta K, MacMicking JD (2021) “A human apolipoprotein L with detergent-like activity kills intracellular pathogens.” Science 373(6552):eabf8113
Wandel MP, Kim BH, Park ES, Boyle KB, Nayak K, Lagrange B, Herod A, Henry T, Zilbauer M, Rohde J, MacMicking JD, Randow F (2020) “Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms” Nature Immunology 21(8):880-891 * Highlighted in Nature Immunology New & Views