PROFILE

우태균 팀장

Inhibition of SOD1 trimerization is a novel drug target for ALS disease

Oral administration of Amisodin in ALS mouse model protected against neuronal loss, and extended the lifespan of ALS mice by up to 3 weeks. The findings indicate that amisodin, which targets trimeric SOD1, may be a strong therapeutic candidate for both familial and sporadic ALS

PRG S&Tech 연구본부

EDUCATION

2006. 03. ~ 2012. 08.
B.S., Department of Molecular Biology, Pusan National University.
2012. 09. ~ 2018. 02.
Ph.D., Department of Integrated Biological Science, Pusan National University.

CONFERENCE PRESENTATIONS

1. 4th Symposium of Rare Genetic Diseases, PRG S&Tech, Development of new drugs for Rare neuropathy, Republic of Korea. (11/2023)
Title : Optimized new SOD1 aggregation inhibitor extends life span of ALS model mouse and protects spinal neurons; implication for ALS treatment
2. 36th Sorak Conference, Korean Society for Biochemistry and Molecular Biology, Republic of Korea. (06/2023)
Title : Development of therapeutics for ALS disease through suppression of SOD1 aggregation

POSTER PRESENTATIONS

1. 2024 ALS Nexus conference. (07/2024)
Title : PRG-A-05: A Novel Drug Candidate for ALS by Targeting Aggregation nucleated from Trimeric SOD1
2. 2022 BIO International Convention (BIO USA_06/2022)
Title : PRG-A-Series for ALS

PUBLICATIONS

1. Woo TG, Han J, Kim Y, Hwang YJ, Lee M, Kang SM, Park S, Ji Y, Chung YH, Baek S, Shin E, Kim M, Jang H, Shin YJ, Kwon Y, Kim BH, Park BJ. (2025) Inhibition of SOD1 trimerization is a novel drug target for ALS disease. Transl Neurodegener. 12;14(1):21
2. Baek Y, Woo TG, Ahn J, Lee D, Kwon Y, Park BJ, Ha NC. (2022) Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation. Commun Biol. 12;5(1):1085
3. Woo TG, Yoon MH, Kang SM, Park S, Cho JH, Hwang YJ, Ahn J, Jang H, Shin YJ, Jung EM, Ha NC, Kim BH, Kwon Y, Park BJ. (2021) Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model. Commun Biol. 15;4(1):1397
4. Ahn J*, Woo TG*, Kang SM, Jo I, Woo JS, Park BJ, Ha NC. (2021) The flavonoid morin alleviates nuclear deformation in aged cells by disrupting progerin-lamin A/C binding. Journal of Functional Foods. Feb 77(104331) * These authors contributed equally to this study