PROFILE

이상배 교수

Deciphering the Oncogenic Signaling Pathway Linking Brain and Liver Cancers

The presentation traces our research on oxygen sensing and protein-stability regulation in cancer, beginning with studies in glioblastoma (GBM), where both ID2 and LZTR1 were first identified in patient-derived tumors. Building on our work on the DYRK1–ID2–VHL–HIF axis, we recently found that KCTD17-mediated destabilization of LZTR1 activates Ras signaling and drives progression and therapeutic resistance in hepatocellular carcinoma. Ongoing studies further investigate the tumor-suppressive role and regulatory mechanisms of LZTR1 in GBM.

KAIST 의과학대학원

EDUCATION

2006-2011, Ph.D., Sungkyunkwan University School of Medicine

2004-2006, M.S., Catholic university School of Medicine

1999-2004, B.S., College of Advanced Science, Dankook university

PROFESSIONAL EXPERIENCE

2023-Present, Department of Biological Sciences, Jeonbuk National University Associate professor

2019-2023, Department of Biological Sciences, Jeonbuk National University Assistant professor

2017-2019, Institute for Cancer Genetics, Columbia University, New York, NY Associate Research Scientist

2013-2017, Institute for Cancer Genetics, Columbia University, New York, NY Postdoctoral Research Scientist

2011-2012, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, PostDoc

RESEARCH ACTIVITIES & OTHERS

Choi Y.D.#, Kim Y.U. #, Gi H.#, Kim D.-W.#, Lee S.B.*, Kim K.* SERPINA3 as a modulator of skin cell functionality in human dermal fibroblasts. BMB Rep. 58(6), 264-268 (2025)
eong Y., Oh A.-R., Jung Y.H., Jung K.H., Carrer M., Lee S.B., Valenti L., Pajvani U.B., Kim K.*, Hepatocyte KCTD17-mediated SERPINA3 inhibition determines liver fibrosis in metabolic dysfunction-associated steatohepatitis. Exp. Mol. Med. ;57(8), 1673-1685 (2025)
Jung Y.H., Lee Y.J., Dao T., Jung K.H., Yu J., Oh A.-R., Jeong Y., Gi H., Kim Y.U., Ryu D., Carrer M., Pajvani U.B., Lee S.B.*, Hong S.-S.*, Kim K.* KCTD17-mediated Ras stabilization promotes hepatocellular carcinoma progression. Clin. Mol. Hepatol. 30(4), 895-913 (2024)
Kim Y.U., Gi H., Jeong E.K., Han S., Seo W.-Y., Kim Y.J.*, Lee S.B.*, Kim K.* Development of a highly effective recombinant protein from Human Collagen Type III Alpha 1 (COL3A1) to enhance human skin cell functionality. BMB Rep. 57(9), 424-429 (2024)
Kim K., Lee S.B.* Regulation of CMGC kinases by hypoxia. BMB Rep. 56(11), 584-593 (2023)
Shin M.C., Jung Y.H., Jeong Y., Oh A.-R., Lee S.B.*, Kim K.* Kctd17-mediated Chop degradation promotes adipogenic differentiation. Biochem Biophys Res Commun. 653, 126-132 (2023)
Oh A.-R.#, Jeong Y.#, Yu J., Tam D.T.M., Kang J.K., Jung Y.H., Im S.-S., Lee S.B., Ryu D., Pajvani U.P.*, Kim K.* Hepatocyte Kctd17 inhibition ameliorates glucose intolerance and hepatic steatosis caused by obesity-induced Chrebp stabilization. Gastroenterology 164(3), 439-453 (2023)
Lee S.B.*, Garofano L., Ko A., D’Angelo F., Frangaj B., Sommer D., Gan Q., Kim K., Cardozo T., Iavarone A.*, Lasorella A.* Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription. Nature Commun. 13(1), 2089 (2022)
Kim K.*, Kang J.K., Jung Y.H., Lee S.B., Rametta R., Dongiovanni P., Valenti L., Pajvani U.B.* Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver. Nature Commun. 12(1), 1822 (2021)